A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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2009, discovery of a completely new phenotype for micro organism in slender nanofluidic slits; and to start with detection of local protein structures along DNA using solid-condition nanopores
But how do morality, the dignity of your individual, my expertise from the this means of everyday living, observe through the movement of atoms? A purely naturalistic point of view fails listed here; a Christian perspective, I do think, is a much more fair technique to interpret these elements of reality.’
Multicolor imaging with the bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Because 2000, Dekker has shifted the leading focus of his operate to biophysics exactly where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This modification of field was driven by his fascination to the amazing performing of Organic molecular structures, along with via the lengthy-phrase viewpoint a large number of attention-grabbing discoveries can be expected Within this discipline.[5] Recent traces of exploration in his biophysics team are during the parts of:[six]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is always that these components jointly make up a living process. The secret of said daily life, I do think, lies while in the interactions, the interaction of Individuals molecules. The massive issue regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from easy molecules to the extremely intricate systems we see right now? We do not know. I want to work on These types of significant, open inquiries.’
Nanopores characterize a sublime and functional Resource to evaluate solitary molecules. We exploration novel detection modes with stable-point out nanopores together with various ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
‘Indeed, I understand men and women were stunned at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to confess that it experienced become a little bit bored, I didn’t learn Considerably anymore. The field went additional into the application side, how you could possibly integrate nanotubes into electronic circuits.
It absolutely was during this period that Dekker carried out investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Quite a few new phenomena have been discovered, ceesdekker.net and he and his investigate group established a number one position During this discipline of research. Dekker and his exploration group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor dependant on an individual nanotube molecule.
Such as, we consider the nucleopore sophisticated, a gateway among the cell nucleus plus the cytoplasm. This is an extremely difficult method and as a consequence challenging to examine inside a mobile, so we use biomimetics. We reconstruct holes and afterwards insert specific components of the nucleopore advanced to review transportation by it at the single-molecule amount.’
‘I am driven by ponder and thoughts. On a material level I locate solutions in physics, but I practical experience my deepest contentment with God. That faith also drives my science and how I handle persons.